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7cty
From Proteopedia
(Difference between revisions)
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<StructureSection load='7cty' size='340' side='right'caption='[[7cty]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='7cty' size='340' side='right'caption='[[7cty]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7cty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[7cty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CTY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GF3:spiro[1H-2-benzofuran-3,4-piperidine]'>GF3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GF3:spiro[1H-2-benzofuran-3,4-piperidine]'>GF3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cty OCA], [https://pdbe.org/7cty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cty RCSB], [https://www.ebi.ac.uk/pdbsum/7cty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cty ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cty OCA], [https://pdbe.org/7cty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cty RCSB], [https://www.ebi.ac.uk/pdbsum/7cty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cty ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/Q8I1R6_PLAF7 Q8I1R6_PLAF7] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Plafa]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Vitsupakorn, D]] | ||
| - | [[Category: Antibiotic]] | ||
| - | [[Category: Antifolate]] | ||
| - | [[Category: Antimalarial]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Fragment]] | ||
| - | [[Category: Oxidoreductase]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Vitsupakorn D]] | ||
Current revision
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), fragment 263, NADP+, dUMP
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