This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7d1x
From Proteopedia
(Difference between revisions)
m (Protected "7d1x" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)== | |
| + | <StructureSection load='7d1x' size='340' side='right'caption='[[7d1x]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7d1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D1X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d1x OCA], [https://pdbe.org/7d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d1x RCSB], [https://www.ebi.ac.uk/pdbsum/7d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d1x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ST2A8_MOUSE ST2A8_MOUSE] Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.<ref>PMID:28442498</ref> <ref>PMID:29685090</ref> <ref>PMID:33872606</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Au WNS]] | ||
| + | [[Category: Wang K]] | ||
Current revision
Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)
| |||||||||||
