7d8b

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==Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways==
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<StructureSection load='7d8b' size='340' side='right'caption='[[7d8b]]' scene=''>
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<StructureSection load='7d8b' size='340' side='right'caption='[[7d8b]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7d8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8B FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8b OCA], [https://pdbe.org/7d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8b RCSB], [https://www.ebi.ac.uk/pdbsum/7d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8b ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8b OCA], [https://pdbe.org/7d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8b RCSB], [https://www.ebi.ac.uk/pdbsum/7d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8b ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Brown CJ]]
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[[Category: Frosi Y]]
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[[Category: Jiang S]]
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[[Category: Lin YC]]

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Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways

PDB ID 7d8b

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