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7dc6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7dc6 is ON HOLD Authors: Yuan, H., Xia, C. Description: Giant panda MHC class I complexes Category: Unreleased Structures Category: Yuan, H...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Giant panda MHC class I complexes== | |
| + | <StructureSection load='7dc6' size='340' side='right'caption='[[7dc6]], [[Resolution|resolution]] 2.68Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7dc6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ailuropoda_melanoleuca Ailuropoda melanoleuca] and [https://en.wikipedia.org/wiki/Canine_coronavirus Canine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DC6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dc6 OCA], [https://pdbe.org/7dc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dc6 RCSB], [https://www.ebi.ac.uk/pdbsum/7dc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dc6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2KT53_AILME B2KT53_AILME] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The viral cytotoxic T lymphocyte (CTL) epitope peptides presented by classical MHC-I molecules require the assembly of a peptide-MHC-I-beta2m (pMHC-I) trimolecular complex for T cell receptor (TCR) recognition, which is the critical activation link for triggering antiviral T cell immunity. Research on T cell immunology in the Ursidae family, especially structural immunology, is still lacking. In this study, the structure of the key trimolecular complex pMHC-I, which binds a peptide from canine distemper virus, was solved for the first time using giant panda as a representative species of Ursidae. The structural characteristics of the giant panda pMHC-I complex (pAime-128), including the unique pockets in the peptide-binding groove (PBG), were analyzed in detail. Comparing the pAime-128 to others in the bear family and extending the comparison to other mammals revealed distinct features. The interaction between MHC-I and beta2m, the features of pAime-128 involved in TCR docking and cluster of differentiation 8 (CD8) binding, the anchor sites in the PBG, and the CTL epitopes of potential viruses that infect pandas were clarified. Unique features of pMHC-I viral antigen presentation in the panda were revealed by solving the three-dimensional (3D) structure of pAime-128. The distinct characteristics of pAime-128 indicate an unusual event that emerged during the evolution of the MHC system in the bear family. These results provide a new platform for research on panda CTL immunity and the design of vaccines for application in the bear family. | ||
| - | + | Crystal structure of the giant panda MHC class I complex: First insights into the viral peptide presentation profile in the bear family.,Yuan H, Ma L, Zhang L, Li X, Xia C Protein Sci. 2020 Dec;29(12):2468-2481. doi: 10.1002/pro.3980. Epub 2020 Oct 30. PMID:33078460<ref>PMID:33078460</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 7dc6" style="background-color:#fffaf0;"></div> |
| - | [[Category: Xia | + | |
| + | ==See Also== | ||
| + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | ||
| + | *[[MHC 3D structures|MHC 3D structures]] | ||
| + | *[[MHC I 3D structures|MHC I 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ailuropoda melanoleuca]] | ||
| + | [[Category: Canine coronavirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xia C]] | ||
| + | [[Category: Yuan H]] | ||
Current revision
Giant panda MHC class I complexes
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