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7epf

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Current revision (16:59, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7epf' size='340' side='right'caption='[[7epf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='7epf' size='340' side='right'caption='[[7epf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7epf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7epf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=J9U:(8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide'>J9U</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=J9U:(8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide'>J9U</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.[https://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7epf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7epf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Du, J]]
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[[Category: Du J]]
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[[Category: Han, S]]
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[[Category: Han S]]
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[[Category: Lin, S]]
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[[Category: Lin S]]
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[[Category: Wang, D]]
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[[Category: Wang D]]
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[[Category: Wu, B]]
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[[Category: Wu B]]
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[[Category: Zhao, Q]]
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[[Category: Zhao Q]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of mGlu2 bound to NAM597

PDB ID 7epf

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