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7f3p

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Current revision (17:09, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7f3p' size='340' side='right'caption='[[7f3p]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='7f3p' size='340' side='right'caption='[[7f3p]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7f3p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7f3p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoanaerobacter_brockii Thermoanaerobacter brockii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isopropanol_dehydrogenase_(NADP(+)) Isopropanol dehydrogenase (NADP(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.80 1.1.1.80] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3p OCA], [https://pdbe.org/7f3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3p RCSB], [https://www.ebi.ac.uk/pdbsum/7f3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3p OCA], [https://pdbe.org/7f3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3p RCSB], [https://www.ebi.ac.uk/pdbsum/7f3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ADH_THEBR ADH_THEBR]] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde.
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[https://www.uniprot.org/uniprot/ADH_THEBR ADH_THEBR] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bi, Y]]
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[[Category: Thermoanaerobacter brockii]]
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[[Category: Gao, J]]
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[[Category: Bi Y]]
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[[Category: Han, X]]
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[[Category: Gao J]]
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[[Category: Li, Q]]
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[[Category: Han X]]
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[[Category: Liu, W D]]
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[[Category: Li Q]]
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[[Category: Qu, G]]
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[[Category: Liu WD]]
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[[Category: Sun, Z T]]
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[[Category: Qu G]]
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[[Category: Wei, H L]]
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[[Category: Sun ZT]]
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[[Category: Alpha/beta dehydrogenase]]
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[[Category: Wei HL]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of a nadp-dependent alcohol dehydrogenase mutant in apo form

PDB ID 7f3p

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