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7wet
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7wet is ON HOLD Authors: Zhang, H., Luo, C. Description: Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela [[Category: Unrele...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela== | |
| + | <StructureSection load='7wet' size='340' side='right'caption='[[7wet]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7wet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WET FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQR:(2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic+acid'>AQR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wet OCA], [https://pdbe.org/7wet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wet RCSB], [https://www.ebi.ac.uk/pdbsum/7wet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wet ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Luo | + | [[Category: Large Structures]] |
| + | [[Category: Luo C]] | ||
| + | [[Category: Zhang H]] | ||
Current revision
Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela
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