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7xad
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal strucutre of PD-L1 and DBL2_02 designed protein binder== | |
| - | + | <StructureSection load='7xad' size='340' side='right'caption='[[7xad]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xad]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Chemical_production_metagenome Chemical production metagenome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XAD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xad OCA], [https://pdbe.org/7xad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xad RCSB], [https://www.ebi.ac.uk/pdbsum/7xad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xad ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chemical production metagenome]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chai Y]] | ||
| + | [[Category: Gao GF]] | ||
| + | [[Category: Han P]] | ||
| + | [[Category: Liu KF]] | ||
| + | [[Category: Pacesa M]] | ||
| + | [[Category: Tan SG]] | ||
| + | [[Category: Xu ZP]] | ||
Current revision
Crystal strucutre of PD-L1 and DBL2_02 designed protein binder
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Categories: Chemical production metagenome | Homo sapiens | Large Structures | Chai Y | Gao GF | Han P | Liu KF | Pacesa M | Tan SG | Xu ZP
