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7xqe

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(New page: '''Unreleased structure''' The entry 7xqe is ON HOLD Authors: Wu, X., Li, C., Zhang, Y., Xu, Y. Description: Crystal Structure of human RORgamma(C455E) LBD in complex with compound XY0...)
Current revision (17:58, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7xqe is ON HOLD
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==Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039==
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<StructureSection load='7xqe' size='340' side='right'caption='[[7xqe]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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Authors: Wu, X., Li, C., Zhang, Y., Xu, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XQE FirstGlance]. <br>
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Description: Crystal Structure of human RORgamma(C455E) LBD in complex with compound XY039
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4I:2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide'>H4I</scene></td></tr>
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[[Category: Zhang, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xqe OCA], [https://pdbe.org/7xqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xqe RCSB], [https://www.ebi.ac.uk/pdbsum/7xqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xqe ProSAT]</span></td></tr>
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[[Category: Wu, X]]
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</table>
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[[Category: Li, C]]
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== Function ==
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[[Category: Xu, Y]]
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li C]]
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[[Category: Wu X]]
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[[Category: Xu Y]]
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[[Category: Zhang Y]]

Current revision

Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039

PDB ID 7xqe

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OCA

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