7xrc

==Crystal Structure of the dimeric Brn2 (Pou3f2) POU domain bound to palindromic MORE DNA==

<StructureSection load='7xrc' size='340' side='right'caption='[[7xrc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>

<table><tr><td colspan='2'>[[7xrc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus Mus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XRC FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xrc OCA], [https://pdbe.org/7xrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xrc RCSB], [https://www.ebi.ac.uk/pdbsum/7xrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xrc ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/PO3F2_HUMAN PO3F2_HUMAN] Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).[UniProtKB:P31360][UniProtKB:P56222]

[[Category: Mus]]

[[Category: Tan DSY]]