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7xrr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human OX2R bound to the insomnia drug lemborexant.== | |
| + | <StructureSection load='7xrr' size='340' side='right'caption='[[7xrr]], [[Resolution|resolution]] 2.89Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7xrr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XRR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NRK:(1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide'>NRK</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xrr OCA], [https://pdbe.org/7xrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xrr RCSB], [https://www.ebi.ac.uk/pdbsum/7xrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xrr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. | ||
| - | + | ==See Also== | |
| - | + | *[[Orexin and Orexin receptor|Orexin and Orexin receptor]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Asada H]] | ||
| + | [[Category: Im D]] | ||
| + | [[Category: Iwata S]] | ||
Current revision
Crystal structure of the human OX2R bound to the insomnia drug lemborexant.
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Categories: Homo sapiens | Large Structures | Asada H | Im D | Iwata S
