This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ihw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1ihw" [edit=sysop:move=sysop])
Current revision (18:41, 29 November 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ihw.png|left|200px]]
 
-
{{STRUCTURE_1ihw| PDB=1ihw | SCENE= }}
+
==SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES==
 +
<StructureSection load='1ihw' size='340' side='right'caption='[[1ihw]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1ihw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IHW FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ihw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihw OCA], [https://pdbe.org/1ihw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ihw RCSB], [https://www.ebi.ac.uk/pdbsum/1ihw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ihw ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/POL_HV1Z6 POL_HV1Z6] Integrase performs the integration of the newly synthesized dsDNA copy of the viral genome into the host chromosome. The integrated DNA is called provirus.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.
-
===SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES===
+
Solution structure of the DNA binding domain of HIV-1 integrase.,Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:7632683<ref>PMID:7632683</ref>
-
{{ABSTRACT_PUBMED_7632683}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1ihw" style="background-color:#fffaf0;"></div>
-
[[1ihw]] is a 2 chain structure of [[HIV integrase]] and [[Retroviral Integrase]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHW OCA].
+
==See Also==
==See Also==
-
*[[HIV integrase|HIV integrase]]
+
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
-
*[[Retroviral Integrase|Retroviral Integrase]]
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:007632683</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Clore, G M.]]
+
[[Category: Large Structures]]
-
[[Category: Ernst, J A.]]
+
[[Category: Clore GM]]
-
[[Category: Gronenborn, A M.]]
+
[[Category: Ernst JA]]
-
[[Category: Lodi, P J.]]
+
[[Category: Gronenborn AM]]
-
[[Category: Aid]]
+
[[Category: Lodi PJ]]
-
[[Category: Dna-binding protein]]
+
-
[[Category: Polyprotein]]
+

Current revision

SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES

PDB ID 1ihw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ihw"
Personal tools