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1j5h

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==Solution Structure of Apo-Neocarzinostatin==
==Solution Structure of Apo-Neocarzinostatin==
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<StructureSection load='1j5h' size='340' side='right' caption='[[1j5h]], [[NMR_Ensembles_of_Models | 44 NMR models]]' scene=''>
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<StructureSection load='1j5h' size='340' side='right'caption='[[1j5h]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1j5h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J5H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1j5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J5H FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j5h RCSB], [http://www.ebi.ac.uk/pdbsum/1j5h PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5h OCA], [https://pdbe.org/1j5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5h RCSB], [https://www.ebi.ac.uk/pdbsum/1j5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1j5h" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
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[[Category: Caddick, S]]
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[[Category: Caddick S]]
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[[Category: Finucane, M D]]
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[[Category: Finucane MD]]
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[[Category: Muskett, F W]]
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[[Category: Muskett FW]]
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[[Category: Urbaniak, M D]]
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[[Category: Urbaniak MD]]
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[[Category: Woolfson, D N]]
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[[Category: Woolfson DN]]
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[[Category: Antibiotic]]
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[[Category: Beta sandwich]]
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[[Category: Igg fold]]
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Current revision

Solution Structure of Apo-Neocarzinostatin

PDB ID 1j5h

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