1jjs

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{{Seed}}
 
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[[Image:1jjs.png|left|200px]]
 
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==NMR Structure of IBiD, A Domain of CBP/p300==
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The line below this paragraph, containing "STRUCTURE_1jjs", creates the "Structure Box" on the page.
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<StructureSection load='1jjs' size='340' side='right'caption='[[1jjs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JJS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjs OCA], [https://pdbe.org/1jjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jjs RCSB], [https://www.ebi.ac.uk/pdbsum/1jjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jjs ProSAT]</span></td></tr>
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{{STRUCTURE_1jjs| PDB=1jjs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transcriptional coactivators CBP and p300 are critical regulators of metazoan gene expression. They associate with many different DNA-bound transcription factors through small, conserved domains. We have identified a compactly folded 46 residue domain in CBP and p300, the IRF-3 binding domain (IBiD), and we have determined its structure by NMR. It has a helical framework containing an apparently flexible polyglutamine loop that participates in ligand binding. Spectroscopic data indicate that induced folding accompanies association of IBiD with its partners, which exhibit no evident sequence similarities. We demonstrate the significance both in vitro and in vivo of interactions between IBiD and a number of diverse partners. Thus, IBiD is an important contributor to signal integration by CBP and p300.
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===NMR Structure of IBiD, A Domain of CBP/p300===
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A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies.,Lin CH, Hare BJ, Wagner G, Harrison SC, Maniatis T, Fraenkel E Mol Cell. 2001 Sep;8(3):581-90. PMID:11583620<ref>PMID:11583620</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jjs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11583620}}, adds the Publication Abstract to the page
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*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11583620 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11583620}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJS OCA].
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==Reference==
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A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies., Lin CH, Hare BJ, Wagner G, Harrison SC, Maniatis T, Fraenkel E, Mol Cell. 2001 Sep;8(3):581-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11583620 11583620]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Fraenkel E]]
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[[Category: Fraenkel, E.]]
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[[Category: Hare BJ]]
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[[Category: Hare, B J.]]
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[[Category: Harrison SC]]
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[[Category: Harrison, S C.]]
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[[Category: Lin CH]]
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[[Category: Lin, C H.]]
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[[Category: Maniatis T]]
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[[Category: Maniatis, T.]]
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[[Category: Wagner G]]
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[[Category: Wagner, G.]]
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[[Category: Coactivator]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:21:14 2008''
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Current revision

NMR Structure of IBiD, A Domain of CBP/p300

PDB ID 1jjs

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