1mp6

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==Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy==
==Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy==
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<StructureSection load='1mp6' size='340' side='right' caption='[[1mp6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='1mp6' size='340' side='right'caption='[[1mp6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1mp6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MP6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1mp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Udorn/307/1972(H3N2)) Influenza A virus (A/Udorn/307/1972(H3N2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MP6 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mp6 RCSB], [http://www.ebi.ac.uk/pdbsum/1mp6 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mp6 OCA], [https://pdbe.org/1mp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mp6 RCSB], [https://www.ebi.ac.uk/pdbsum/1mp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mp6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M2_I72A2 M2_I72A2]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).<ref>PMID:7508997</ref>
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[https://www.uniprot.org/uniprot/M2_I72A2 M2_I72A2] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).<ref>PMID:7508997</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1mp6" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
*[[M2 protein|M2 protein]]
*[[M2 protein|M2 protein]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cross, T A]]
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[[Category: Large Structures]]
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[[Category: Kim, S]]
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[[Category: Cross TA]]
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[[Category: Kovacs, F]]
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[[Category: Kim S]]
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[[Category: Wang, J]]
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[[Category: Kovacs F]]
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[[Category: Influenza a virus]]
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[[Category: Wang J]]
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[[Category: M2 proton channel]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein structure]]
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[[Category: Solid state nmr]]
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Current revision

Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy

PDB ID 1mp6

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