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1mpv

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Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

Structural highlights

1mpv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

TR13C_HUMAN Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.^[1]

Function

TR13C_HUMAN B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.^[2] ^[3]

Publication Abstract from PubMed

The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.,Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM Immunity. 2002 Oct;17(4):515-24. PMID:12387744^[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Warnatz K, Salzer U, Rizzi M, Fischer B, Gutenberger S, Bohm J, Kienzler AK, Pan-Hammarstrom Q, Hammarstrom L, Rakhmanov M, Schlesier M, Grimbacher B, Peter HH, Eibel H. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13945-50. doi:, 10.1073/pnas.0903543106. Epub 2009 Aug 6. PMID:19666484 doi:10.1073/pnas.0903543106
↑ Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, Cancro M, Grewal IS, Dixit VM. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol. 2001 Oct 2;11(19):1547-52. PMID:11591325
↑ Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 2002 Oct;17(4):515-24. PMID:12387744
↑ Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 2002 Oct;17(4):515-24. PMID:12387744

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpv"

@@ Line 1: / Line 1: @@
-[[Image:1mpv.gif|left|200px]]<br />
-<applet load="1mpv" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1mpv" />
-'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''<br />
-==Overview==
+==Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide==
-The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It, binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling, promotes processing of the transcription factor NF-kappaB2/p100 to p52., NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice, possessing a mutant BR3 gene, but not in TACI or BCMA null B cells., Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein, showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1, mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2, processing and attenuated the disease process. Since inhibiting the, BR3-BAFF interaction has therapeutic ramifications, the ligand binding, interface of BR3 was investigated and found to reside within a 26 residue, core domain. When stabilized within a structured beta-hairpin peptide, six, of these residues were sufficient to confer binding to BAFF.
+<StructureSection load='1mpv' size='340' side='right'caption='[[1mpv]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpv OCA], [https://pdbe.org/1mpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpv RCSB], [https://www.ebi.ac.uk/pdbsum/1mpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpv ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[https://omim.org/entry/613494 613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref> <ref>PMID:12387744</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
-==About this Structure==
+BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.,Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM Immunity. 2002 Oct;17(4):515-24. PMID:12387744<ref>PMID:12387744</ref>
-MPV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE and NH2 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12387744 12387744]
+</div>
-[[Category: Single protein]]
+<div class="pdbe-citations 1mpv" style="background-color:#fffaf0;"></div>
-[[Category: Cochran, A.G.]]
+== References ==
-[[Category: Dixit, V.M.]]
+<references/>
-[[Category: French, D.M.]]
+__TOC__
-[[Category: Gordon, N.C.]]
+</StructureSection>
-[[Category: Grewal, I.S.]]
+[[Category: Homo sapiens]]
-[[Category: Kayagaki, N.]]
+[[Category: Large Structures]]
-[[Category: Lee, W.]]
+[[Category: Cochran AG]]
-[[Category: Seshasayee, D.]]
+[[Category: Dixit VM]]
-[[Category: Starovasnik, M.A.]]
+[[Category: French DM]]
-[[Category: Wang, H.]]
+[[Category: Gordon NC]]
-[[Category: Yan, M.]]
+[[Category: Grewal IS]]
-[[Category: Yin, J.]]
+[[Category: Kayagaki N]]
-[[Category: ACE]]
+[[Category: Lee W]]
-[[Category: NH2]]
+[[Category: Seshasayee D]]
-[[Category: beta-hairpin]]
+[[Category: Starovasnik MA]]
+[[Category: Wang H]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:13:41 2007''
+[[Category: Yan M]]
+[[Category: Yin J]]

1mpv

From Proteopedia

Current revision

Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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