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1mxn

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==Solution structure of alpha-conotoxin AuIB==
==Solution structure of alpha-conotoxin AuIB==
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<StructureSection load='1mxn' size='340' side='right' caption='[[1mxn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1mxn' size='340' side='right'caption='[[1mxn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1mxn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MXN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1mxn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MXN FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mxp|1mxp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxn OCA], [http://pdbe.org/1mxn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mxn RCSB], [http://www.ebi.ac.uk/pdbsum/1mxn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxn OCA], [https://pdbe.org/1mxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mxn RCSB], [https://www.ebi.ac.uk/pdbsum/1mxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mxn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CA1B_CONAL CA1B_CONAL]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.<ref>PMID:9786965</ref>
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[https://www.uniprot.org/uniprot/CA1B_CONAL CA1B_CONAL] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.<ref>PMID:9786965</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adams, D J]]
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[[Category: Conus aulicus]]
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[[Category: Alewood, P F]]
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[[Category: Large Structures]]
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[[Category: Bansal, P S]]
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[[Category: Adams DJ]]
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[[Category: Craik, D J]]
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[[Category: Alewood PF]]
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[[Category: Dutton, J L]]
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[[Category: Bansal PS]]
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[[Category: Hogg, R C]]
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[[Category: Craik DJ]]
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[[Category: Alpha helix]]
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[[Category: Dutton JL]]
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[[Category: Toxin]]
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[[Category: Hogg RC]]

Current revision

Solution structure of alpha-conotoxin AuIB

PDB ID 1mxn

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