1oz8

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(New page: 200px<br /><applet load="1oz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oz8" /> '''Intramolecular higher-order packing of paral...)
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[[Image:1oz8.gif|left|200px]]<br /><applet load="1oz8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oz8" />
 
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'''Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA'''<br />
 
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==Overview==
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==Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA==
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GGA triplet repeats are widely dispersed throughout eukaryotic genomes and, are frequently located within biologically important regions such as gene, regulatory regions and recombination hot spot sites. We determined the, structure of d(GGA)4 (12-mer) under physiological conditions and founded, the formation of an intramolecular parallel quadruplex for the first time., Later, a similar architecture to that of the intramolecular parallel, quadruplex was found for a telomere DNA in the crystalline state. Here, we, have determined the structure of d(GGA)8 (24-mer) under physiological, conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G, tetrad and a G(:A):G(:A):G(:A):G heptad are formed in d(GGA)8. These, quadruplexes are packed in a tail-to-tail manner. This is the first, demonstration of the intramolecular higher order packing of quadruplexes, at atomic resolution. K+ ions, but not Na+ ones, are critically required, for the formation of this unique structure. The elucidated structure, suggests the mechanisms underlying the biological events related to the, GGA triplet repeat. Furthermore, in the light of the structure, the mode, of the higher order packing of the telomere DNA is discussed.
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<StructureSection load='1oz8' size='340' side='right'caption='[[1oz8]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1oz8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz8 OCA], [https://pdbe.org/1oz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1oz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz8 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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GGA triplet repeats are widely dispersed throughout eukaryotic genomes and are frequently located within biologically important regions such as gene regulatory regions and recombination hot spot sites. We determined the structure of d(GGA)4 (12-mer) under physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a similar architecture to that of the intramolecular parallel quadruplex was found for a telomere DNA in the crystalline state. Here, we have determined the structure of d(GGA)8 (24-mer) under physiological conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad are formed in d(GGA)8. These quadruplexes are packed in a tail-to-tail manner. This is the first demonstration of the intramolecular higher order packing of quadruplexes at atomic resolution. K+ ions, but not Na+ ones, are critically required for the formation of this unique structure. The elucidated structure suggests the mechanisms underlying the biological events related to the GGA triplet repeat. Furthermore, in the light of the structure, the mode of the higher order packing of the telomere DNA is discussed.
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==About this Structure==
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Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA.,Matsugami A, Okuizumi T, Uesugi S, Katahira M J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:12748183<ref>PMID:12748183</ref>
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1OZ8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12748183 12748183]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1oz8" style="background-color:#fffaf0;"></div>
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[[Category: Katahira, M.]]
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== References ==
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[[Category: Matsugami, A.]]
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<references/>
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[[Category: Okuizumi, T.]]
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__TOC__
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[[Category: Uesugi, S.]]
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</StructureSection>
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[[Category: intramolecular packing of parallel quadruplexes]]
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[[Category: Large Structures]]
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[[Category: Katahira M]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:43:00 2007''
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[[Category: Matsugami A]]
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[[Category: Okuizumi T]]
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[[Category: Uesugi S]]

Current revision

Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA

PDB ID 1oz8

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