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1pg1

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1pg1", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1pg1.png|left|200px]]
 
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==PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1pg1", creates the "Structure Box" on the page.
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<StructureSection load='1pg1' size='340' side='right'caption='[[1pg1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PG1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1pg1| PDB=1pg1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pg1 OCA], [https://pdbe.org/1pg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pg1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pg1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PG1_PIG PG1_PIG] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: The protegrins are a family of arginine- and cysteine-rich cationic peptides found in porcine leukocytes that exhibit a broad range of antimicrobial and antiviral activities. They are composed of 16-18 amino-acid residues including four cysteines, which form two disulfide linkages. To begin to understand the mechanism of action of these peptides, we set out to determine the structure of protegrin-1 (PG-1). RESULTS: We used two-dimensional homonuclear nuclear magnetic resonance spectroscopy to study the conformation of both natural and synthetic PG-1 under several conditions. A refined three-dimensional structure of synthetic PG-1 is presented. CONCLUSIONS: Both synthetic and natural protegrin-1 form a well-defined structure in solution composed primarily of a two-stranded antiparallel beta sheet, with strands connected by a beta turn. The structure of PG-1 suggests ways in which the peptide may interact with itself or other molecules to form the membrane pores and the large membrane-associated assemblages observed in protegrin-treated, gram-negative bacteria.
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===PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES===
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Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.,Fahrner RL, Dieckmann T, Harwig SS, Lehrer RI, Eisenberg D, Feigon J Chem Biol. 1996 Jul;3(7):543-50. PMID:8807886<ref>PMID:8807886</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1pg1" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8807886}}, adds the Publication Abstract to the page
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*[[Protegrin|Protegrin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8807886 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8807886}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1pg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PG1 OCA].
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==Reference==
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<ref group="xtra">PMID:008807886</ref><references group="xtra"/>
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Dieckmann, T.]]
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[[Category: Dieckmann T]]
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[[Category: Eisenberg, D.]]
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[[Category: Eisenberg D]]
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[[Category: Fahrner, R L.]]
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[[Category: Fahrner RL]]
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[[Category: Feigon, J.]]
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[[Category: Feigon J]]
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[[Category: Harwig, S S.L.]]
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[[Category: Harwig SSL]]
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[[Category: Lehrer, R I.]]
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[[Category: Lehrer RI]]
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[[Category: Antimicrobial peptide]]
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Current revision

PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES

PDB ID 1pg1

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