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5o66

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==Asymmetric AcrABZ-TolC==
==Asymmetric AcrABZ-TolC==
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<StructureSection load='5o66' size='340' side='right' caption='[[5o66]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
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<SX load='5o66' size='340' side='right' viewer='molstar' caption='[[5o66]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5o66]] is a 15 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5v78 5v78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O66 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5o66]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5v78 5v78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O66 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o66 OCA], [http://pdbe.org/5o66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o66 RCSB], [http://www.ebi.ac.uk/pdbsum/5o66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o66 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o66 OCA], [https://pdbe.org/5o66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o66 RCSB], [https://www.ebi.ac.uk/pdbsum/5o66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o66 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACRZ_ECO57 ACRZ_ECO57]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.[HAMAP-Rule:MF_01484] [[http://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI]] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref> [[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> [[http://www.uniprot.org/uniprot/ACRA_ECO57 ACRA_ECO57]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together (By similarity).
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[https://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Du, D]]
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[[Category: Escherichia coli K-12]]
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[[Category: Luisi, B F]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Membrane protein]]
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[[Category: Large Structures]]
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[[Category: Membrane transporter]]
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[[Category: Du D]]
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[[Category: Multidrug efflux pump]]
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[[Category: Luisi BF]]

Current revision

Asymmetric AcrABZ-TolC

5o66, resolution 5.90Å

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