4gfu

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{{STRUCTURE_4gfu| PDB=4gfu | SCENE= }}
 
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===PTPN18 in complex with HER2-pY1248 phosphor-peptides===
 
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==Function==
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==PTPN18 in complex with HER2-pY1248 phosphor-peptides==
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[[http://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN]] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
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<StructureSection load='4gfu' size='340' side='right'caption='[[4gfu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfu OCA], [https://pdbe.org/4gfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfu RCSB], [https://www.ebi.ac.uk/pdbsum/4gfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
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==About this Structure==
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==See Also==
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[[4gfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFU OCA].
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Du, Y J.]]
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[[Category: Du YJ]]
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[[Category: Sun, J P.]]
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[[Category: Sun JP]]
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[[Category: Wang, H M.]]
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[[Category: Wang HM]]
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[[Category: Yang, D X.]]
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[[Category: Yang DX]]
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[[Category: Yang, F.]]
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[[Category: Yang F]]
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[[Category: Yu, X.]]
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[[Category: Yu X]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-peptide complex]]
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[[Category: Phosphatase]]
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[[Category: Tyrosine phosphorylation]]
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Current revision

PTPN18 in complex with HER2-pY1248 phosphor-peptides

PDB ID 4gfu

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