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7xk2

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m (Protected "7xk2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7xk2 is ON HOLD
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==Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex==
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<StructureSection load='7xk2' size='340' side='right'caption='[[7xk2]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xk2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XK2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FI7:2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic+acid'>FI7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xk2 OCA], [https://pdbe.org/7xk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7xk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xk2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: DiBerto JF]]
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[[Category: Gao RG]]
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[[Category: Han GW]]
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[[Category: Kang HJ]]
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[[Category: Kenakin T]]
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[[Category: Li XM]]
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[[Category: Liu ZJ]]
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[[Category: Peng W]]
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[[Category: Pileski R]]
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[[Category: Qu L]]
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[[Category: Rao ZH]]
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[[Category: Roth BL]]
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[[Category: Stevens RC]]
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[[Category: Tong JH]]
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[[Category: Wang JJ]]
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[[Category: Wang Q]]
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[[Category: Wu LJ]]
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[[Category: Wu YR]]
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[[Category: Yang Y]]
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[[Category: Zhang XC]]
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[[Category: Zhao SW]]

Current revision

Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex

PDB ID 7xk2

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