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1pqr

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Current revision (09:17, 6 December 2023) (edit) (undo)
 
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==Solution Conformation of alphaA-Conotoxin EIVA==
==Solution Conformation of alphaA-Conotoxin EIVA==
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<StructureSection load='1pqr' size='340' side='right'caption='[[1pqr]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
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<StructureSection load='1pqr' size='340' side='right'caption='[[1pqr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pqr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_ermineus Conus ermineus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQR FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqr OCA], [https://pdbe.org/1pqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pqr RCSB], [https://www.ebi.ac.uk/pdbsum/1pqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pqr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqr OCA], [https://pdbe.org/1pqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pqr RCSB], [https://www.ebi.ac.uk/pdbsum/1pqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pqr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CA4A_CONER CA4A_CONER]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin binds with high affinity to both fetal (alpha-1/beta-1/epsilon/delta subunits) and adult (alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR).
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[https://www.uniprot.org/uniprot/CA4A_CONER CA4A_CONER] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin binds with high affinity to both fetal (alpha-1/beta-1/epsilon/delta subunits) and adult (alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Conus ermineus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chi, S W]]
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[[Category: Chi S-W]]
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[[Category: Han, K H]]
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[[Category: Han K-H]]
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[[Category: McIntosh, J M]]
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[[Category: McIntosh JM]]
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[[Category: Olivera, B M]]
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[[Category: Olivera BM]]
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[[Category: Park, K H]]
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[[Category: Park K-H]]
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[[Category: Suk, J E]]
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[[Category: Suk J-E]]
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[[Category: Alpha-helix]]
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[[Category: C-term amidation]]
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[[Category: Toxin]]
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[[Category: Two disulfide bond]]
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Current revision

Solution Conformation of alphaA-Conotoxin EIVA

PDB ID 1pqr

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