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1q2k

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{{Seed}}
 
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[[Image:1q2k.png|left|200px]]
 
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==Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch==
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The line below this paragraph, containing "STRUCTURE_1q2k", creates the "Structure Box" on the page.
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<StructureSection load='1q2k' size='340' side='right'caption='[[1q2k]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q2K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q2k OCA], [https://pdbe.org/1q2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q2k RCSB], [https://www.ebi.ac.uk/pdbsum/1q2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q2k ProSAT]</span></td></tr>
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{{STRUCTURE_1q2k| PDB=1q2k | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KA191_MESMA KA191_MESMA] Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific.<ref>PMID:15178692</ref> [PDB:3E8Y]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BmBKTx1 is a 31-amino acid peptide identified from the venom of the Chinese scorpion Buthus martensi Karsch, blocking high-conductance calcium-activated potassium channels. Sequence homology analysis indicates that BmBKTx1 is a new subfamily of short-chain alpha-KTx toxins of the potassium channel, which we term alpha-KTx19. Synthetic BmBKTx1 was prepared by using solid-phase peptide synthesis. Two-dimensional NMR spectroscopy techniques were used to determine the solution structure of BmBKTx1. The results show that the BmBKTx1 forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins. The structure of BmBKTx1 consists of a two-stranded antiparallel beta-sheet (residues 20-29) and an alpha-helix (residues 5-15). The three-dimensional structure of BmBKTx1 was also compared with those of two function-related scorpion toxins, charybdotoxin (ChTx) and BmTx1, and their structural and functional implications are discussed.
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===Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch===
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Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch.,Cai Z, Xu C, Xu Y, Lu W, Chi CW, Shi Y, Wu J Biochemistry. 2004 Apr 6;43(13):3764-71. PMID:15049683<ref>PMID:15049683</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1q2k" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15049683}}, adds the Publication Abstract to the page
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15049683 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15049683}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1Q2K is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2K OCA].
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[[Category: Mesobuthus martensii]]
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[[Category: Cai Z]]
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==Reference==
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[[Category: Chi CW]]
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Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch., Cai Z, Xu C, Xu Y, Lu W, Chi CW, Shi Y, Wu J, Biochemistry. 2004 Apr 6;43(13):3764-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15049683 15049683]
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[[Category: Lu W]]
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[[Category: Single protein]]
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[[Category: Shi Y]]
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[[Category: Cai, Z.]]
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[[Category: Wu J]]
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[[Category: Chi, C W.]]
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[[Category: Xu C]]
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[[Category: Lu, W.]]
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[[Category: Xu Y]]
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[[Category: Shi, Y.]]
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[[Category: Wu, J.]]
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[[Category: Xu, C.]]
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[[Category: Xu, Y.]]
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[[Category: Alpha-helix]]
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[[Category: Beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:05:48 2008''
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Current revision

Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch

PDB ID 1q2k

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