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1sso

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[[Image:1sso.jpg|left|200px]]
 
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==SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS==
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The line below this paragraph, containing "STRUCTURE_1sso", creates the "Structure Box" on the page.
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<StructureSection load='1sso' size='340' side='right'caption='[[1sso]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sso OCA], [https://pdbe.org/1sso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sso RCSB], [https://www.ebi.ac.uk/pdbsum/1sso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sso ProSAT]</span></td></tr>
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{{STRUCTURE_1sso| PDB=1sso | SCENE= }}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS'''
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[https://www.uniprot.org/uniprot/DN7A_SACS2 DN7A_SACS2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The archaeon Sulfolobus solfataricus expresses large amounts of a small basic protein, Sso7d, which was previously identified as a DNA-binding protein possibly involved in compaction of DNA. We have determined the solution structure of Sso7d. The protein consists of a triple-stranded anti-parallel beta-sheet onto which an orthogonal double-stranded beta-sheet is packed. This topology is very similar to that found in eukaryotic Src homology-3 (SH3) domains. Sso7d binds strongly (Kd &lt; 10 microM) to double-stranded DNA and protects it from thermal denaturation. In addition, we note that epsilon-mono-methylation of lysine side chains of Sso7d is governed by cell growth temperatures, suggesting that methylation is related to the heat-shock response.
The archaeon Sulfolobus solfataricus expresses large amounts of a small basic protein, Sso7d, which was previously identified as a DNA-binding protein possibly involved in compaction of DNA. We have determined the solution structure of Sso7d. The protein consists of a triple-stranded anti-parallel beta-sheet onto which an orthogonal double-stranded beta-sheet is packed. This topology is very similar to that found in eukaryotic Src homology-3 (SH3) domains. Sso7d binds strongly (Kd &lt; 10 microM) to double-stranded DNA and protects it from thermal denaturation. In addition, we note that epsilon-mono-methylation of lysine side chains of Sso7d is governed by cell growth temperatures, suggesting that methylation is related to the heat-shock response.
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==About this Structure==
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Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus.,Baumann H, Knapp S, Lundback T, Ladenstein R, Hard T Nat Struct Biol. 1994 Nov;1(11):808-19. PMID:7634092<ref>PMID:7634092</ref>
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1SSO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus., Baumann H, Knapp S, Lundback T, Ladenstein R, Hard T, Nat Struct Biol. 1994 Nov;1(11):808-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634092 7634092]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1sso" style="background-color:#fffaf0;"></div>
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[[Category: Sulfolobus solfataricus]]
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== References ==
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[[Category: Baumann, H.]]
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<references/>
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[[Category: Hard, T.]]
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__TOC__
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[[Category: Knapp, S.]]
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</StructureSection>
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[[Category: Ladenstein, R.]]
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[[Category: Large Structures]]
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[[Category: Lundback, T.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Dna-binding protein]]
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[[Category: Baumann H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:05:48 2008''
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[[Category: Hard T]]
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[[Category: Knapp S]]
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[[Category: Ladenstein R]]
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[[Category: Lundback T]]

Current revision

SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS

PDB ID 1sso

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