1t5q
From Proteopedia
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| - | [[Image:1t5q.png|left|200px]] | ||
| - | + | ==Solution Structure of GIP(1-30)amide in TFE/Water== | |
| + | <StructureSection load='1t5q' size='340' side='right'caption='[[1t5q]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1t5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T5Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5q OCA], [https://pdbe.org/1t5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t5q RCSB], [https://www.ebi.ac.uk/pdbsum/1t5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists. | ||
| - | + | NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.,Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230<ref>PMID:15522230</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1t5q" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | + | [[Category: Homo sapiens]] | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Alana I]] |
| - | [[Category: | + | [[Category: Gault VA]] |
| - | [[Category: | + | [[Category: Hewage CM]] |
| - | [[Category: | + | [[Category: Malthouse JPG]] |
| - | [[Category: | + | [[Category: O'Harte FPM]] |
| - | [[Category: | + | [[Category: Parker JC]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
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Current revision
Solution Structure of GIP(1-30)amide in TFE/Water
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