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5o9s

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==HsNMT1 in complex with CoA and Myristoylated-GKSNSKLK octapeptide==
==HsNMT1 in complex with CoA and Myristoylated-GKSNSKLK octapeptide==
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<StructureSection load='5o9s' size='340' side='right' caption='[[5o9s]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5o9s' size='340' side='right'caption='[[5o9s]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5o9s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O9S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5o9s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O9S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9s OCA], [http://pdbe.org/5o9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9s RCSB], [http://www.ebi.ac.uk/pdbsum/5o9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9s OCA], [https://pdbe.org/5o9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o9s RCSB], [https://www.ebi.ac.uk/pdbsum/5o9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. [[http://www.uniprot.org/uniprot/NCS1_HUMAN NCS1_HUMAN]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
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[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Dian, C]]
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[[Category: Large Structures]]
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[[Category: Giglione, C]]
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[[Category: Dian C]]
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[[Category: Meinnel, T]]
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[[Category: Giglione C]]
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[[Category: Acyltransferase]]
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[[Category: Meinnel T]]
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[[Category: Coa]]
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[[Category: Glycylpeptide n-tetradecanoyltransferase 1 n-myristoyltransferase 1]]
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[[Category: Gnat]]
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[[Category: Myr-coa]]
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[[Category: Myr-peptide]]
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[[Category: Myristoyl]]
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[[Category: N-myristoyltransferase type1]]
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[[Category: Nmt]]
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[[Category: Nmt1]]
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[[Category: Transferase]]
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Current revision

HsNMT1 in complex with CoA and Myristoylated-GKSNSKLK octapeptide

PDB ID 5o9s

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