Succinate-semialdehyde dehydrogenase

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(New page: <StructureSection load='3vz3' size='340' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3).' scene=...)
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<StructureSection load='' size='350' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code [[3vz3]]).' scene='59/590825/Cv/2'>
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<StructureSection load='3vz3' size='340' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code [[3vz3]]).' scene=''>
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== Function ==
== Function ==
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'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism.
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'''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' or '''succinyl-CoA reductase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. See also [[Aldehyde dehydrogenase]].
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== Disease ==
== Disease ==
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== Relevance ==
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SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia<ref>PMID:15341910</ref>.
== Structural highlights ==
== Structural highlights ==
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The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/11'>cofactor NADP</scene><ref>PMID:23500184</ref>. Water molecules are shown as red spheres. <scene name='59/590825/Cv/12'>Whole binding site</scene>.
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</StructureSection>
==3D structures of succinate-semialdehyde dehydrogenase==
==3D structures of succinate-semialdehyde dehydrogenase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Succinate-semialdehyde dehydrogenase
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[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
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**[[2w8n]], [[2w8o]] – hSSD - human <br />
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[[3vz2]] – SySSD (mutant) <br />
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**[[2w8p]] – hSSD (mutant) <br />
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[[3ifg]], [[3ifh]] – SSD – ''Burkholderia pseudomallei''<br />
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**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
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[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
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**[[3vz2]] – SySSD (mutant) <br />
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[[2w8n]], [[2w8o]] – hSSD - human <br />
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**[[4v6h]] – SSD – ''Burkholderia pseudomallei''<br />
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[[2w8p]] – hSSD (mutant) <br />
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**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br />
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**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
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**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br />
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**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br />
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'''Succinate-semialdehyde dehydrogenase complexes'''
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*Succinate-semialdehyde dehydrogenase complexes
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[[2w8q]] – hSSD (mutant) + succinate<br />
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**[[2w8q]] – hSSD (mutant) + succinate<br />
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[[2w8r]] – hSSD (mutant) + ADP<br />
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**[[2w8r]] – hSSD (mutant) + ADP<br />
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[[4ita]] – SySSD + NADPH<br />
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**[[4ita]] – SySSD + NADPH<br />
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[[4itb]] – SySSD + NADPH + succinic semialdehyde<br />
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**[[4itb]] – SySSD + NADPH + succinic semialdehyde<br />
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[[3vz3]] – SySSD (mutant) + NADPH + succinic semialdehyde<br />
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**[[3vz3]] – SySSD (mutant) + NADPH + succinic semialdehyde<br />
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[[3jz4]] – SSD + NADPH – ''Escherichia coli''<br />
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**[[3jz4]] – SSD + NADPH – ''Escherichia coli''<br />
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**[[4oht]] – SpSSD + NADPH<br />
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**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br />
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**[[5x5u]] – AbSSD + NAD<br />
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**[[8c54]] – SSD + NADH – ''Rhizobium leguminosarum'' – Cryo EM<br />
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**[[8cej]] – CkSSD + mesaconyl-c1-CoA – ''Clostridium kluyveri''<br />
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**[[8cek]] – CkSSD + NADPH<br />
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}}
== References ==
== References ==

Current revision

Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3).

Drag the structure with the mouse to rotate

3D structures of succinate-semialdehyde dehydrogenase

Updated on 06-December-2023

References

  1. ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
  2. ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
  3. ↑ Yuan Z, Yin B, Wei D, Yuan YR. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase. J Struct Biol. 2013 May;182(2):125-35. doi: 10.1016/j.jsb.2013.03.001. Epub 2013 , Mar 13. PMID:23500184 doi:10.1016/j.jsb.2013.03.001

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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