SUMO conjugating enzyme Ubc9

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<StructureSection load='' size='350' side='right' scene='SUMO_conjugating_enzyme_Ubc9/Cv/1' caption='SUMO conjugating enzyme Ubc9 tetramer [[2gjd]]'>
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{{STRUCTURE_2gjd| PDB=2gjd | SIZE=300| SCENE=SUMO_conjugating_enzyme_Ubc9/Cv/1 |right|CAPTION=SUMO conjugating enzyme Ubc9 tetramer [[2gjd]] }}
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== Function ==
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[[SUMO conjugating enzyme Ubc9]] accepts the ubiquitin-like SUMOs and catalyzes their attachment to other proteins with the help of E3 ligase<ref>PMID:23644018</ref>.
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[[SUMO conjugating enzyme Ubc9]] accepts the ubiquitin-like SUMOs and catalyzes their attachment to other proteins with the help of E3 ligase. The images at the left and at the right correspond to one representative yeast SUMO conjugating enzyme Ubc9 ([[2gjd]]).
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== Relevance ==
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Ubc9 inhibitors may be therapeutic agents against fibrotic diseases like rheumatoid arthritis<ref>PMID:22904261</ref><ref>PMID:24531852</ref>.
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</StructureSection>
== 3D Structures of SUMO conjugating enzyme Ubc9 ==
== 3D Structures of SUMO conjugating enzyme Ubc9 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2gjd]] – yUbc9 - yeast<br />
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*Ubc9
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[[1a3s]] - hUbc9 - human<br />
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[[1u9a]] - mUbc9 - mouse<br />
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[[1u9b]] - mUbc9 (mutant)<br />
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[[4jue]], [[4m1n]] – Ubc9 – ''Plasmodium falciparum''<br />
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===Ubc9 complexes===
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**[[1a3s]] - hUbc9 - human<br />
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**[[5f6e]] – hUbc9 (mutant)<br />
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**[[1u9a]] - mUbc9 - mouse<br />
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**[[1u9b]] - mUbc9 (mutant)<br />
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**[[2gjd]] – yUbc9 - yeast<br />
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**[[4jue]], [[4m1n]] – Ubc9 – ''Plasmodium falciparum''<br />
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[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br />
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*Ubc9 complexes
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[[2eke]] – yUbc9+SMT3<br />
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[[2xwu]] – hUbc9+importin13 <br />
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[[2px9]] – hUbc9+SUMO2<br />
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[[2pe6]] - hUbc9+SUMO1<br />
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[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br />
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[[2grn]] - hUbc9+ RAN GTPase activating protein 1 C-terminal<br />
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[[1kps]] - hUbc9+ RAN GTPase activating protein 1 <br />
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[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br />
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[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + small ubiquitin-related modifier 2 + RANBP2<br />
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[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br />
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[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br />
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[[2vrr]], [[2uyz]] – mUbc9+SUMO1 <br />
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[[3rcz]] – Ubc9 + DNA repair protein SUMO-like domain – ''Schizosaccharomyces pombe''<br />
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**[[2xwu]] – hUbc9+importin13 <br />
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**[[2px9]] – hUbc9+SUMO2<br />
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**[[2pe6]], [[8odr]] - hUbc9+SUMO1<br />
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**[[4y1l]] – hUbc9 + RSUME<br />
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**[[6q83]] – hUbc9 + KAP122<br />
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**[[6syf]] – hUbc9 + peptide<br />
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**[[5f6d]], [[5f6u]], [[5f6v]], [[5f6w]], [[5f6x]], [[5f6y]] – hUbc9 (mutant) + inhibitor<br />
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**[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br />
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**[[2grn]] - hUbc9+ RAN GTPase activating protein 1 C-terminal<br />
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**[[1kps]] - hUbc9+ RAN GTPase activating protein 1 <br />
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**[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br />
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**[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + RANBP2<br />
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**[[4w5v]], [[5fq2]] - hUbc9+ SUMO activating enzyme <br />
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**[[5d2m]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + ZNF451<br />
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**[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br />
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**[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br />
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**[[2vrr]], [[2uyz]] – mUbc9+SUMO1 <br />
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**[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br />
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**[[2eke]] – yUbc9+SMT3<br />
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**[[5jne]] – yUbc9 + SMT3 + PCNA + SIZ1<br />
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**[[7p47]] – yUbc9 + SMT3 + MMS21 + SMC5<br />
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**[[3rcz]] – Ubc9 + DNA repair protein SUMO-like domain – fission yeast<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

SUMO conjugating enzyme Ubc9 tetramer 2gjd

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3D Structures of SUMO conjugating enzyme Ubc9

Updated on 10-December-2023

References

  1. ↑ Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A. Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013, May 2. PMID:23644018 doi:http://dx.doi.org/10.1016/j.molcel.2013.03.027
  2. ↑ Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH. Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub, 2012 Aug 17. PMID:22904261 doi:http://dx.doi.org/10.1136/annrheumdis-2012-201746
  3. ↑ Li F, Li X, Kou L, Li Y, Meng F, Ma F. SUMO-conjugating enzyme UBC9 promotes proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2014 Aug;37(4):1134-41. doi: 10.1007/s10753-014-9837-x. PMID:24531852 doi:http://dx.doi.org/10.1007/s10753-014-9837-x

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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