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Syntrophin

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<StructureSection load='1qav' size='340' side='right' caption='Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code [[1qav]])' scene=''>
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<StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'>
== Function ==
== Function ==
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Syntrophins (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>.
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'''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. Syn binds the neuronal NOS β-finger via its binding groove<ref>PMID:10221915</ref>.
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Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>.
</StructureSection>
</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*α-1-syntrophin
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*alpha-1-syntrophin
**[[1z86]] – mSyn PDZ domain – mouse - NMR <br />
**[[1z86]] – mSyn PDZ domain – mouse - NMR <br />
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**[[2pdz]] – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR <br />
**[[2pdz]] – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR <br />
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*β-2-syntrophin
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*beta-1-syntrophin
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**[[7pc4]] – hSyn PDZ domain 107-196 + TAX-1 peptide - human<br />
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**[[7p70]] – hSyn PDZ domain + HPV35-E6 peptide <br />
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*beta-2-syntrophin
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**[[2vrf]] – hSyn PDZ domain <br />
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*gamma-1-syntrophin
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**[[7qqn]] – hSyn PDZ domain 54-143 + TRPV3 peptide <br />
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**[[7pc7]] – hSyn PDZ domain + PTEN peptide <br />
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**[[7pc8]] – hSyn PDZ domain + RSK1 peptide <br />
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*gamma-2-syntrophin
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**[[7qql]] – hSyn PDZ domain 70-159 + RSK1 peptide <br />
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**[[2vrf]] – Syn PDZ domain – human <br />
 
}}
}}
== References ==
== References ==

Current revision

Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code 1qav)

Drag the structure with the mouse to rotate

3D Structures of syntrophin

Updated on 12-December-2023

References

  1. ↑ Bhat HF, Adams ME, Khanday FA. Syntrophin proteins as Santa Claus: role(s) in cell signal transduction. Cell Mol Life Sci. 2013 Jul;70(14):2533-54. doi: 10.1007/s00018-012-1233-9. Epub , 2012 Dec 21. PMID:23263165 doi:http://dx.doi.org/10.1007/s00018-012-1233-9
  2. ↑ Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Moss AJ, Shimizu W, Towbin JA, Cheng J, Vatta M. alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ Arrhythm Electrophysiol. 2008 Aug;1(3):193-201. doi:, 10.1161/CIRCEP.108.769224. PMID:19684871 doi:http://dx.doi.org/10.1161/CIRCEP.108.769224
  3. ↑ Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 1999 Apr 30;284(5415):812-5. PMID:10221915

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