Talin

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(New page: Crystal Structure of Talin 2x0c {{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE= |right|CAPTION=Talin 2x0c }} Talin is involved in cell-cell con...)
Current revision (09:58, 12 December 2023) (edit) (undo)
 
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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
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<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
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{{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE= |right|CAPTION=Talin [[2x0c]] }}
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Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 vinculin binding sites VBS1-VBS3.
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[[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
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</StructureSection>
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== 3D Structures of Talin ==
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[[Talin 3D structures]]
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Talin subdomains
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== References ==
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<references/>
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2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
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</StructureSection>
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2kma – mTal F0F1 – NMR
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[[Category: Topic Page]]
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2kc1 - mTal F0 – NMR
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2kc2 - mTal F1 – NMR
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2hrj - cTal F2 – NMR
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1mix – cTal F2F3
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2kgx – mTal F3+mTal fragment – NMR
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Integrin binding sites
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2jsw, 2qdq – mTal IBS – NMR
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3g9w – mTal F2F3+integrin tail
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1miz, 1mk7, 1mk9 - hTal+integrin tail
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2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
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3fyq – Tal rod IBS2 – Drosophila melanogaster
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Vinculin binding sites
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2kvp, 2b0h – mTal VBS3 – NMR
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1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
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1u6h - cTal VBS2+ vinculin head
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1t01 - cTal VBS1+ vinculin head
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1syq - hTal VBS1+ vinculin head – human
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1rkc - hTal VBS3+ vinculin head
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1u89 - mTal VBS2 – NMR
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PIP kinase binding sites
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1y19 - mTal F2F3+ PIP kinase C-terminal
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2g35 - mTal F3+PIP kinase peptide – NMR
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Layilin binding sites
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2k00 - cTal F3+layilin fragment – NMR
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Current revision

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin

Talin 3D structures

References

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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