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Talin

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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
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<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
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{{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
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[[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
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{{TOC limit|limit=2}}
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[[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
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</StructureSection>
== 3D Structures of Talin ==
== 3D Structures of Talin ==
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[[Talin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== References ==
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<references/>
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=== Talin subdomains ===
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</StructureSection>
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[[Category: Topic Page]]
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[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
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[[2kma]] – mTal F0F1 – NMR<br />
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[[2kc1]] - mTal F0 – NMR<br />
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[[2kc2]] - mTal F1 – NMR<br />
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[[2hrj]] - cTal F2 – NMR <br />
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[[1mix]] – cTal F2F3<br />
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[[4f7g]] - mTal F2F3 + rod segment domain<br />
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[[2kgx]] – mTal F3+mTal fragment – NMR<br />
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[[3ivf]] – mTal FERM domain<br />
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[[2l7n]] – mTal B – NMR<br />
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[[2l10]] – mTal C - NMR<br />
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[[2lqg]] - mTal R4 helix – NMR<br />
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=== Talin integrin-binding sites ===
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[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
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[[3g9w]] – mTal2 F2F3+integrin tail<br />
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[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
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[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
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[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
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=== Talin vinculin-binding sites ===
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[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
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[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
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[[1u6h]] - cTal VBS2+ vinculin head<br />
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[[1t01]] - cTal VBS1+ vinculin head<br />
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[[1syq]] - hTal VBS1+ vinculin head – human<br />
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[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br />
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[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
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[[4dj9]] – hTal VBS50 + vinculin head
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=== Talin PIP kinase binding sites ===
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[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
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[[2g35]] - mTal F3+PIP kinase peptide – NMR
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=== Layilin binding sites ===
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[[2k00]] - cTal F3+layilin fragment – NMR
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[[Category:Topic Page]]
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Current revision

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin

Talin 3D structures

References

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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