8f9c

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Current revision (11:40, 13 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8f9c is ON HOLD until Paper Publication
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==Compound 20 bound to procaspase-6==
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<StructureSection load='8f9c' size='340' side='right'caption='[[8f9c]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Fan, P., Zhao, Y., Renslo, A.R., Arkin, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8f9c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F9C FirstGlance]. <br>
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Description: Compound 20 bound to procaspase-6
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XN9:5-fluoro-2-({[(3M)-3-(4H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}methyl)phenol'>XN9</scene></td></tr>
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[[Category: Renslo, A.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f9c OCA], [https://pdbe.org/8f9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f9c RCSB], [https://www.ebi.ac.uk/pdbsum/8f9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f9c ProSAT]</span></td></tr>
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[[Category: Arkin, M.R]]
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</table>
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[[Category: Zhao, Y]]
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== Function ==
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[[Category: Fan, P]]
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[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arkin MR]]
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[[Category: Fan P]]
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[[Category: Renslo AR]]
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[[Category: Zhao Y]]

Current revision

Compound 20 bound to procaspase-6

PDB ID 8f9c

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OCA

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