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1e3k

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==HUMAN PROGESTERON RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)==
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<StructureSection load='1e3k' size='340' side='right' caption='[[1e3k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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==Human Progesteron Receptor Ligand Binding Domain in complex with the ligand metribolone (R1881)==
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<StructureSection load='1e3k' size='340' side='right'caption='[[1e3k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3K FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE'>R18</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE'>R18</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3k RCSB], [http://www.ebi.ac.uk/pdbsum/1e3k PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3k OCA], [https://pdbe.org/1e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3k RCSB], [https://www.ebi.ac.uk/pdbsum/1e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3k ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3k_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3k_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e3k ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1e3k" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Progesterone receptor|Progesterone receptor]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Basler, S.]]
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[[Category: Large Structures]]
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[[Category: Carrondo, M A.]]
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[[Category: Basler S]]
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[[Category: Coelho, R.]]
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[[Category: Carrondo MA]]
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[[Category: Donner, P.]]
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[[Category: Coelho R]]
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[[Category: Egner, U.]]
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[[Category: Donner P]]
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[[Category: Joschko, S.]]
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[[Category: Egner U]]
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[[Category: Macedo, S.]]
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[[Category: Joschko S]]
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[[Category: Matias, P M.]]
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[[Category: Macedo S]]
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[[Category: Otto, N.]]
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[[Category: Matias PM]]
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[[Category: Peixoto, C.]]
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[[Category: Otto N]]
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[[Category: Schafer, M.]]
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[[Category: Peixoto C]]
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[[Category: Scholz, P.]]
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[[Category: Schafer M]]
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[[Category: Thomaz, M.]]
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[[Category: Scholz P]]
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[[Category: Wegg, A.]]
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[[Category: Thomaz M]]
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[[Category: Human progesterone receptor]]
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[[Category: Wegg A]]
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[[Category: Ligand binding domain]]
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Current revision

Human Progesteron Receptor Ligand Binding Domain in complex with the ligand metribolone (R1881)

PDB ID 1e3k

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