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1e6j

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==Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5==
==Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5==
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<StructureSection load='1e6j' size='340' side='right' caption='[[1e6j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1e6j' size='340' side='right'caption='[[1e6j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The July 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''HIV Capsid'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_7 10.2210/rcsb_pdb/mom_2013_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E6J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e6j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_M:B_HXB2R HIV-1 M:B_HXB2R] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The July 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''HIV Capsid'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_7 10.2210/rcsb_pdb/mom_2013_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6J FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1afv|1afv]], [[1a80|1a80]], [[1tam|1tam]], [[1esk|1esk]], [[1e6o|1e6o]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6j OCA], [http://pdbe.org/1e6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e6j RCSB], [http://www.ebi.ac.uk/pdbsum/1e6j PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6j OCA], [https://pdbe.org/1e6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6j RCSB], [https://www.ebi.ac.uk/pdbsum/1e6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAG_HV1H2 GAG_HV1H2]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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[https://www.uniprot.org/uniprot/Q99LC4_MOUSE Q99LC4_MOUSE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/1e6j_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/1e6j_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Virus coat protein|Virus coat protein]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: HIV Capsid]]
[[Category: HIV Capsid]]
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[[Category: Hiv-1]]
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[[Category: HIV-1 M:B_HXB2R]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Berthet-Colominas, C]]
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[[Category: Berthet-Colominas C]]
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[[Category: Cusack, S]]
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[[Category: Cusack S]]
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[[Category: Mallet, F]]
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[[Category: Mallet F]]
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[[Category: Monaco, S]]
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[[Category: Monaco S]]
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[[Category: Novelli, A]]
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[[Category: Novelli A]]
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[[Category: Sibai, G]]
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[[Category: Sibai G]]
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[[Category: Antibody]]
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[[Category: Antigen]]
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[[Category: Ca]]
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[[Category: Capsid]]
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[[Category: Fab]]
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[[Category: P24]]
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[[Category: Protein-protein interaction]]
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[[Category: Viral protein]]
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[[Category: Virus assembly]]
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Current revision

Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5

PDB ID 1e6j

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