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1gu4

From Proteopedia

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[[Image:1gu4.png|left|200px]]
 
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==Crystal structure of C/EBPBETA BZIP homodimer bound to a high affinity DNA fragment==
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The line below this paragraph, containing "STRUCTURE_1gu4", creates the "Structure Box" on the page.
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<StructureSection load='1gu4' size='340' side='right'caption='[[1gu4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GU4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gu4 OCA], [https://pdbe.org/1gu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gu4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gu4 ProSAT]</span></td></tr>
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{{STRUCTURE_1gu4| PDB=1gu4 | SCENE= }}
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</table>
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== Function ==
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===CRYSTAL STRUCTURE OF C/EBPBETA BZIP DIMERIC BOUND TO A HIGH AFFINITY DNA FRAGMENT===
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[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11792321}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11792321 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1gu4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11792321}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gu4 ConSurf].
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[[1gu4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU4 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:11792321</ref><ref group="xtra">PMID:11375506</ref><ref group="xtra">PMID:11257229</ref><ref group="xtra">PMID:11375505</ref><ref group="xtra">PMID:11679735</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ogata, K.]]
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[[Category: Large Structures]]
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[[Category: Tahirov, T H.]]
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[[Category: Synthetic construct]]
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[[Category: Bzip]]
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[[Category: Ogata K]]
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[[Category: C/ebp]]
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[[Category: Tahirov TH]]
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[[Category: Hypothetical protein]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription factor]]
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[[Category: Transcription/dna]]
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Current revision

Crystal structure of C/EBPBETA BZIP homodimer bound to a high affinity DNA fragment

PDB ID 1gu4

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