1gwc

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[[Image:1gwc.png|left|200px]]
 
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==The structure of a tau class glutathione S-transferase from wheat, active in herbicide detoxification==
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The line below this paragraph, containing "STRUCTURE_1gwc", creates the "Structure Box" on the page.
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<StructureSection load='1gwc' size='340' side='right'caption='[[1gwc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gwc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aegilops_tauschii Aegilops tauschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1gwc| PDB=1gwc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwc OCA], [https://pdbe.org/1gwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwc RCSB], [https://www.ebi.ac.uk/pdbsum/1gwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O04941_AEGTA O04941_AEGTA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutathione S-transferases (GSTs) from the phi (GSTF) and tau (GSTU) classes are unique to plants and play important roles in stress tolerance and secondary metabolism as well as catalyzing the detoxification of herbicides in crops and weeds. We have cloned and functionally characterized a group of GSTUs from wheat treated with fenchlorazole-ethyl, a herbicide safener. One of these enzymes, TaGSTU4-4, was highly active in conjugating the chemically distinct wheat herbicides fenoxaprop and dimethenamid. The structure of TaGSTU4-4 has been determined at 2.2 A resolution in complex with S-hexylglutathione. This enzyme is the first tau class GST structure to be determined and most closely resembles the omega class GSTs, but without the unique N-terminal extension or active site cysteine. The X-ray structure identifies key amino acid residues in the hydrophobic binding site and provides insights into the substrate specificity of these enzymes.
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===THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION===
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Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification.,Thom R, Cummins I, Dixon DP, Edwards R, Cole DJ, Lapthorn AJ Biochemistry. 2002 Jun 4;41(22):7008-20. PMID:12033934<ref>PMID:12033934</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gwc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12033934}}, adds the Publication Abstract to the page
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12033934 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12033934}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1gwc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aegilops_tauschii Aegilops tauschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWC OCA].
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==Reference==
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<ref group="xtra">PMID:012033934</ref><ref group="xtra">PMID:009276955</ref><references group="xtra"/>
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[[Category: Aegilops tauschii]]
[[Category: Aegilops tauschii]]
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[[Category: Glutathione transferase]]
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[[Category: Large Structures]]
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[[Category: Cole, D J.]]
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[[Category: Cole DJ]]
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[[Category: Cummins, I.]]
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[[Category: Cummins I]]
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[[Category: Dixon, D P.]]
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[[Category: Dixon DP]]
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[[Category: Edwards, R.]]
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[[Category: Edwards R]]
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[[Category: Lapthorn, A J.]]
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[[Category: Lapthorn AJ]]
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[[Category: Thom, R.]]
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[[Category: Thom R]]
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[[Category: Glutathione s-transferase]]
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[[Category: Herbicide detoxification]]
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[[Category: Plant]]
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[[Category: Tau class]]
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[[Category: Transferase]]
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Current revision

The structure of a tau class glutathione S-transferase from wheat, active in herbicide detoxification

PDB ID 1gwc

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