1h0r

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(New page: 200px<br /> <applet load="1h0r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h0r, resolution 2.10&Aring;" /> '''TYPE II DEHYDROQUIN...)
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[[Image:1h0r.gif|left|200px]]<br />
 
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<applet load="1h0r" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1h0r, resolution 2.10&Aring;" />
 
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'''TYPE II DEHYDROQUINASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH 2,3-ANHYDRO-QUINIC ACID'''<br />
 
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==About this Structure==
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==Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid==
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1H0R is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with PO4, CL, FA1 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H0R OCA]].
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<StructureSection load='1h0r' size='340' side='right'caption='[[1h0r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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[[Category: Mycobacterium tuberculosis]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1h0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. The April 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Concanavalin A and Circular Permutation'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_4 10.2210/rcsb_pdb/mom_2010_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0R FirstGlance]. <br>
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[[Category: Abell, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Coggins, J.R.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FA1:2,3+-ANHYDRO-QUINIC+ACID'>FA1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Frederickson, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0r OCA], [https://pdbe.org/1h0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0r RCSB], [https://www.ebi.ac.uk/pdbsum/1h0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0r ProSAT]</span></td></tr>
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[[Category: Lapthorn, A.J.]]
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</table>
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[[Category: Robinson, D.A.]]
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== Function ==
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[[Category: Roszak, A.W.]]
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[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[[Category: CL]]
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== Evolutionary Conservation ==
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[[Category: FA1]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: GOL]]
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Check<jmol>
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[[Category: PO4]]
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<jmolCheckbox>
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[[Category: aromatic amino acid biosynthesis]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0r_consurf.spt"</scriptWhenChecked>
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[[Category: dehydratase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: lyase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: shikimate pathway]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0r ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:32:29 2007''
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==See Also==
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*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Concanavalin A and Circular Permutation]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Abell C]]
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[[Category: Coggins JR]]
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[[Category: Frederickson M]]
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[[Category: Lapthorn AJ]]
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[[Category: Robinson DA]]
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[[Category: Roszak AW]]

Current revision

Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid

PDB ID 1h0r

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