1hci

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==CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ==
==CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ==
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<StructureSection load='1hci' size='340' side='right' caption='[[1hci]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='1hci' size='340' side='right'caption='[[1hci]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HCI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h8b|1h8b]], [[1quu|1quu]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hci RCSB], [http://www.ebi.ac.uk/pdbsum/1hci PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hci OCA], [https://pdbe.org/1hci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hci RCSB], [https://www.ebi.ac.uk/pdbsum/1hci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hci ProSAT]</span></td></tr>
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<table>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/1hci_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/1hci_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hci ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1hci" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Actinin|Actinin]]
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*[[Actinin 3D structures|Actinin 3D structures]]
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*[[Group:MUZIC:actinin2|MUZIC:actinin2]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Saraste, M.]]
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[[Category: Large Structures]]
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[[Category: Scheffzek, K.]]
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[[Category: Saraste M]]
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[[Category: Ylanne, J.]]
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[[Category: Scheffzek K]]
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[[Category: Young, P.]]
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[[Category: Ylanne J]]
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[[Category: Actin-binding protein]]
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[[Category: Young P]]
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[[Category: Contractile protein]]
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[[Category: Z-disk]]
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[[Category: Muscle]]
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[[Category: Triple-helix coiled coil]]
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[[Category: Z-line]]
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Current revision

CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ

PDB ID 1hci

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