1o7t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:29, 13 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1o7t.png|left|200px]]
 
-
<!--
+
==Metal nanoclusters bound to the Ferric Binding Protein from Neisseria gonorrhoeae.==
-
The line below this paragraph, containing "STRUCTURE_1o7t", creates the "Structure Box" on the page.
+
<StructureSection load='1o7t' size='340' side='right'caption='[[1o7t]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1o7t]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7T FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HF3:SMALLEST+HF-OXO-PHOSPHATE+CLUSTER+HF3'>HF3</scene>, <scene name='pdbligand=HF5:HF+OXO+CLUSTER+HF5'>HF5</scene>, <scene name='pdbligand=PHF:HF-OXO-PHOSPHATE+CLUSTER+PHF'>PHF</scene></td></tr>
-
{{STRUCTURE_1o7t| PDB=1o7t | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7t OCA], [https://pdbe.org/1o7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7t RCSB], [https://www.ebi.ac.uk/pdbsum/1o7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7t ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q50964_NEIGO Q50964_NEIGO]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7t_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7t ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Transferrins transport Fe3+ and other metal ions in mononuclear-binding sites. We present the first evidence that a member of the transferrin superfamily is able to recognize multi-nuclear oxo-metal clusters, small mineral fragments that are the most abundant forms of many metals in the environment. We show that the ferric ion-binding protein from Neisseria gonorrhoeae (nFbp) readily binds clusters of Fe3+, Ti4+, Zr4+ or Hf4+ in solution. The 1.7 A resolution crystal structure of Hf-nFbp reveals three distinct types of clusters in an open, positively charged cleft between two hinged protein domains. A di-tyrosyl cluster nucleation motif (Tyr195-Tyr196) is situated at the bottom of this cleft and binds either a trinuclear oxo-Hf cluster, which is capped by phosphate, or a pentanuclear cluster, which in turn can be capped with phosphate. This first high-resolution structure of a protein-mineral interface suggests a novel metal-uptake mechanism and provides a model for protein-mediated mineralization/dissimilation, which plays a critical role in geochemical processes.
-
===METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.===
+
A novel protein-mineral interface.,Alexeev D, Zhu H, Guo M, Zhong W, Hunter DJ, Yang W, Campopiano DJ, Sadler PJ Nat Struct Biol. 2003 Apr;10(4):297-302. PMID:12598891<ref>PMID:12598891</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1o7t" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_12598891}}, adds the Publication Abstract to the page
+
*[[Ferric-binding protein|Ferric-binding protein]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 12598891 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12598891}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1O7T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA].
+
-
 
+
-
==Reference==
+
-
A novel protein-mineral interface., Alexeev D, Zhu H, Guo M, Zhong W, Hunter DJ, Yang W, Campopiano DJ, Sadler PJ, Nat Struct Biol. 2003 Apr;10(4):297-302. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12598891 12598891]
+
[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
-
[[Category: Single protein]]
+
[[Category: Alexeev D]]
-
[[Category: Alexeev, D.]]
+
[[Category: Campopiano DJ]]
-
[[Category: Campopiano, D J.]]
+
[[Category: Guo M]]
-
[[Category: Guo, M.]]
+
[[Category: Hunter DJB]]
-
[[Category: Hunter, D J.B.]]
+
[[Category: Sadler PJ]]
-
[[Category: Sadler, P J.]]
+
[[Category: Yang W]]
-
[[Category: Yang, W.]]
+
[[Category: Zhong W]]
-
[[Category: Zhong, W.]]
+
[[Category: Zu H]]
-
[[Category: Zu, H.]]
+
-
[[Category: Hafnium]]
+
-
[[Category: Metal-oxo cluster]]
+
-
[[Category: Periplasmic ferric binding protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:44:51 2008''
+

Current revision

Metal nanoclusters bound to the Ferric Binding Protein from Neisseria gonorrhoeae.

PDB ID 1o7t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o7t"
Personal tools