1o8c

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{{Seed}}
 
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[[Image:1o8c.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF E. COLI K-12 YHDH WITH BOUND NADPH==
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The line below this paragraph, containing "STRUCTURE_1o8c", creates the "Structure Box" on the page.
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<StructureSection load='1o8c' size='340' side='right'caption='[[1o8c]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o8c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_1o8c| PDB=1o8c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8c OCA], [https://pdbe.org/1o8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8c RCSB], [https://www.ebi.ac.uk/pdbsum/1o8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACUI_ECOLI ACUI_ECOLI] Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA.<ref>PMID:22563425</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o8c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As part of a structural genomics project on bacterial gene products of unknown function, the crystal structures of YhdH, a putative quinone oxidoreductase, and its complex with NADP have been determined at 2.25 and 2.6 A resolution, respectively. The overall fold of YhdH is very similar to that of alcohol dehydrogenases and quinone reductases despite its low sequence identity. The absence of any Zn ion indicates that YdhH is a putative quinone oxidoreductase. YhdH forms a homodimer, with each subunit composed of two domains: a catalytic domain and a coenzyme-binding domain. NADP is bound in a deep cleft formed between the two domains. Large conformational changes occur upon NADP binding, with the two domains closing up to each other and narrowing the NADP-binding cleft. Comparisons of the YdhH active site with those of the quinone oxidoreductases from Escherichia coli and Thermus thermophilus made it possible to identify essential conserved residues as being Asn41, Asp43, Asp64 and Arg318. The active-site size is very narrow and unless an induced fit occurs is accessible only to reagents the size of benzoquinone.
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===CRYSTAL STRUCTURE OF E. COLI K-12 YHDH WITH BOUND NADPH===
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Structure of Escherichia coli YhdH, a putative quinone oxidoreductase.,Sulzenbacher G, Roig-Zamboni V, Pagot F, Grisel S, Salomoni A, Valencia C, Campanacci V, Vincentelli R, Tegoni M, Eklund H, Cambillau C Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1855-62. Epub 2004, Sep 23. PMID:15388933<ref>PMID:15388933</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15388933}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1o8c" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15388933 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15388933}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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1O8C is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8C OCA].
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[[Category: Large Structures]]
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[[Category: Bignon C]]
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==Reference==
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[[Category: Cambillau C]]
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<ref group="xtra">PMID:15388933</ref><references group="xtra"/>
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[[Category: Grisel S]]
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[[Category: Escherichia coli]]
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[[Category: Pagot F]]
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[[Category: Bignon, C.]]
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[[Category: Roig-Zamboni V]]
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[[Category: Cambillau, C.]]
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[[Category: Salamoni A]]
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[[Category: Grisel, S.]]
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[[Category: Sulzenbacher G]]
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[[Category: Pagot, F.]]
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[[Category: Tegoni M]]
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[[Category: Roig-Zamboni, V.]]
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[[Category: Valencia C]]
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[[Category: Salamoni, A.]]
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[[Category: Vincentelli R]]
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[[Category: Sulzenbacher, G.]]
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[[Category: Tegoni, M.]]
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[[Category: Valencia, C.]]
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[[Category: Vincentelli, R.]]
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[[Category: Possible nadph-dependent quinone oxidoreductase]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:40:38 2009''
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Current revision

CRYSTAL STRUCTURE OF E. COLI K-12 YHDH WITH BOUND NADPH

PDB ID 1o8c

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