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1ok9

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==DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.==
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<StructureSection load='1ok9' size='340' side='right' caption='[[1ok9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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==Decay accelerating factor (CD55): The structure of an intact human complement regulator.==
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<StructureSection load='1ok9' size='340' side='right'caption='[[1ok9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ok9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OK9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ok9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OK9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h03|1h03]], [[1h04|1h04]], [[1h2p|1h2p]], [[1h2q|1h2q]], [[1m11|1m11]], [[1nwv|1nwv]], [[1ojv|1ojv]], [[1ojw|1ojw]], [[1ojy|1ojy]], [[1ok1|1ok1]], [[1ok2|1ok2]], [[1ok3|1ok3]], [[1uot|1uot]], [[1upn|1upn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ok9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ok9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ok9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ok9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ok9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ok9 OCA], [https://pdbe.org/1ok9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ok9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ok9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ok9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1ok9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1ok9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ok9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1ok9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD55|CD55]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Billington, J]]
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[[Category: Large Structures]]
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[[Category: Crispin, M D.M]]
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[[Category: Billington J]]
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[[Category: Dwek, R A]]
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[[Category: Crispin MDM]]
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[[Category: Esser, D]]
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[[Category: Dwek RA]]
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[[Category: Evans, D J]]
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[[Category: Esser D]]
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[[Category: Lea, S M]]
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[[Category: Evans DJ]]
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[[Category: Lukacik, P]]
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[[Category: Lea SM]]
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[[Category: Morgan, B P]]
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[[Category: Lukacik P]]
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[[Category: Radcliffe, C M]]
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[[Category: Morgan BP]]
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[[Category: Roversi, P]]
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[[Category: Radcliffe CM]]
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[[Category: Rudd, P M]]
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[[Category: Roversi P]]
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[[Category: Smith, G P]]
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[[Category: Rudd PM]]
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[[Category: Smith, R A.G]]
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[[Category: Smith GP]]
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[[Category: White, J]]
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[[Category: Smith RAG]]
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[[Category: Williams, P A]]
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[[Category: White J]]
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[[Category: Wormald, M R]]
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[[Category: Williams PA]]
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[[Category: Decay acceleration of c3/c5 convertase]]
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[[Category: Wormald MR]]
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[[Category: Immune system protein]]
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[[Category: Pathogen receptor]]
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[[Category: Regulator of complement]]
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[[Category: Regulator of complement pathway]]
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[[Category: Short consensus repeat domain]]
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Current revision

Decay accelerating factor (CD55): The structure of an intact human complement regulator.

PDB ID 1ok9

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