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1umr

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==Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus==
==Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus==
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<StructureSection load='1umr' size='340' side='right' caption='[[1umr]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='1umr' size='340' side='right'caption='[[1umr]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1umr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UMR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1umr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UMR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c3a|1c3a]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1umr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1umr OCA], [http://pdbe.org/1umr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1umr RCSB], [http://www.ebi.ac.uk/pdbsum/1umr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1umr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1umr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1umr OCA], [https://pdbe.org/1umr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1umr RCSB], [https://www.ebi.ac.uk/pdbsum/1umr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1umr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLA_CRODU SLA_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref> [[http://www.uniprot.org/uniprot/SLB_CRODU SLB_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref>
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[https://www.uniprot.org/uniprot/SLA_CRODU SLA_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Crotalus durissus terrificus]]
[[Category: Crotalus durissus terrificus]]
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[[Category: Arni, R K]]
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[[Category: Large Structures]]
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[[Category: Cintra, A C.O]]
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[[Category: Arni RK]]
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[[Category: Gava, L M]]
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[[Category: Cintra ACO]]
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[[Category: Michelan-Duarte, S]]
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[[Category: Gava LM]]
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[[Category: Murakami, M T]]
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[[Category: Michelan-Duarte S]]
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[[Category: Zela, S P]]
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[[Category: Murakami MT]]
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[[Category: Activator]]
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[[Category: Zela SP]]
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[[Category: C-type lectin]]
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[[Category: Lectin]]
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[[Category: Platelet]]
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[[Category: Snake venom]]
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[[Category: Sugar binding protein]]
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[[Category: Sugar-binding protein]]
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Current revision

Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus

PDB ID 1umr

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