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1uwf

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==1.7 A RESOLUTION STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE FIMH ADHESIN FROM UROPATHOGENIC E. COLI==
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<StructureSection load='1uwf' size='340' side='right' caption='[[1uwf]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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==1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli==
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<StructureSection load='1uwf' size='340' side='right'caption='[[1uwf]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uwf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uwf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_J96 Escherichia coli J96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UWF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kiu|1kiu]], [[1klf|1klf]], [[1qun|1qun]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uwf RCSB], [http://www.ebi.ac.uk/pdbsum/1uwf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwf OCA], [https://pdbe.org/1uwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uwf RCSB], [https://www.ebi.ac.uk/pdbsum/1uwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwf ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uwf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uwf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uwf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1uwf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli J96]]
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[[Category: Berglund, J.]]
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[[Category: Large Structures]]
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[[Category: Bouckaert, J.]]
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[[Category: Berglund J]]
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[[Category: Cools, L.]]
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[[Category: Bouckaert J]]
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[[Category: Genst, E De.]]
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[[Category: Cools L]]
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[[Category: Greve, H De.]]
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[[Category: De Greve H]]
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[[Category: Hultgren, S J.]]
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[[Category: Genst ED]]
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[[Category: Hung, C S.]]
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[[Category: Hultgren S]]
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[[Category: Knight, S D.]]
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[[Category: Hung C-S]]
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[[Category: Langermann, S.]]
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[[Category: Knight SD]]
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[[Category: Oscarson, S.]]
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[[Category: Langermann S]]
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[[Category: Wuhrer, M.]]
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[[Category: Oscarson S]]
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[[Category: Wyns, L.]]
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[[Category: Wuhrer M]]
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[[Category: Zavialov, A.]]
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[[Category: Wyns L]]
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[[Category: Adherence to mammalian cell]]
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[[Category: Zavialov A]]
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[[Category: Bacterial adhesin]]
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[[Category: Carbohydrate recognition]]
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[[Category: Cell adhesion]]
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[[Category: Ig-variable fold]]
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Current revision

1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli

PDB ID 1uwf

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