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1vyq

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==NOVEL INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE PROVIDE A PLATFORM FOR ANTI-MALARIAL DRUG DESIGN==
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<StructureSection load='1vyq' size='340' side='right' caption='[[1vyq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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==Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design==
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<StructureSection load='1vyq' size='340' side='right'caption='[[1vyq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1vyq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1vyq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUX:2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE'>DUX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUX:2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE'>DUX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyq OCA], [http://pdbe.org/1vyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyq RCSB], [http://www.ebi.ac.uk/pdbsum/1vyq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyq OCA], [https://pdbe.org/1vyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyq RCSB], [https://www.ebi.ac.uk/pdbsum/1vyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8II92_PLAF7 Q8II92_PLAF7]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyq_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyq_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
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*[[DUTPase 3D structures|DUTPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plaf7]]
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[[Category: Large Structures]]
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[[Category: DUTP diphosphatase]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Bell, E]]
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[[Category: Bell E]]
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[[Category: Benito, A]]
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[[Category: Benito A]]
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[[Category: Berry, C]]
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[[Category: Berry C]]
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[[Category: Brun, R]]
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[[Category: Brun R]]
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[[Category: Dodson, E J]]
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[[Category: Dodson EJ]]
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[[Category: Gilbert, I H]]
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[[Category: Gilbert IH]]
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[[Category: Johansson, N G]]
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[[Category: Gonzalez Pacanowska D]]
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[[Category: Jones, A F]]
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[[Category: Johansson NG]]
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[[Category: Kasinathan, G]]
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[[Category: Jones AF]]
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[[Category: Leal, I]]
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[[Category: Kasinathan G]]
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[[Category: Nguyen, C]]
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[[Category: Leal I]]
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[[Category: Pacanowska, D Gonzalez]]
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[[Category: Nguyen C]]
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[[Category: Perez, L M.Ruiz]]
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[[Category: Ruiz Perez LM]]
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[[Category: Turkenburg, J P]]
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[[Category: Turkenburg JP]]
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[[Category: Whittingham, J L]]
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[[Category: Whittingham JL]]
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[[Category: Wilkinson, A J]]
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[[Category: Wilkinson AJ]]
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[[Category: Wilson, K S]]
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[[Category: Wilson KS]]
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[[Category: Deoxyuridine nucleotidohydrolase]]
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[[Category: Drug design]]
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[[Category: Dutpase]]
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[[Category: Hydrolase]]
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[[Category: Malaria]]
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[[Category: Plasmodium falciparum]]
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Current revision

Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design

PDB ID 1vyq

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