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1w4n
From Proteopedia
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| - | [[Image:1w4n.gif|left|200px]]<br /> | ||
| - | <applet load="1w4n" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1w4n, resolution 1.65Å" /> | ||
| - | '''AGAO COVALENT COMPLEX WITH TRANYLCYPROMINE'''<br /> | ||
| - | == | + | ==AGAO covalent complex with Tranylcypromine== |
| - | + | <StructureSection load='1w4n' size='340' side='right'caption='[[1w4n]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1w4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4N FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCQ:(1S,2R)-N-{(1E)-5-[(2S)-2-AMINO-2-CARBOXYETHYL]-2-HYDROXY-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE}-2-PHENYLCYCLOPROPANAMINIUM'>TCQ</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4n OCA], [https://pdbe.org/1w4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4n RCSB], [https://www.ebi.ac.uk/pdbsum/1w4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4n ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/PAOX_ARTGO PAOX_ARTGO] |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4n_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w4n ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | <div style="background-color:#fffaf0;"> | |
| - | + | == Publication Abstract from PubMed == | |
| - | + | Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation. | |
| - | + | ||
| - | [ | + | |
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.,Langley DB, Trambaiolo DM, Duff AP, Dooley DM, Freeman HC, Guss JM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):577-83. Epub 2008 Jun 11. PMID:18607080<ref>PMID:18607080</ref> | |
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1w4n" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arthrobacter globiformis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dooley DM]] | ||
| + | [[Category: Duff AP]] | ||
| + | [[Category: Freeman HC]] | ||
| + | [[Category: Guss JM]] | ||
| + | [[Category: Juda GA]] | ||
| + | [[Category: Langley DB]] | ||
| + | [[Category: Shepard EM]] | ||
| + | [[Category: Trambaiolo DM]] | ||
Current revision
AGAO covalent complex with Tranylcypromine
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