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1w55

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<StructureSection load='1w55' size='340' side='right'caption='[[1w55]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1w55' size='340' side='right'caption='[[1w55]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w55]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp. jejuni" smibert 1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W55 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W55 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w55 OCA], [http://pdbe.org/1w55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w55 RCSB], [http://www.ebi.ac.uk/pdbsum/1w55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w55 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w55 OCA], [https://pdbe.org/1w55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w55 RCSB], [https://www.ebi.ac.uk/pdbsum/1w55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w55 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISPDF_CAMJE ISPDF_CAMJE]] Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).[HAMAP-Rule:MF_01520]
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[https://www.uniprot.org/uniprot/ISPDF_CAMJE ISPDF_CAMJE] Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).[HAMAP-Rule:MF_01520]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1w55" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1w55" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[MEP cytidylyltransferase 3D structures|MEP cytidylyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]
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[[Category: Campylobacter jejuni]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bond, C S]]
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[[Category: Bond CS]]
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[[Category: Gabrielsen, M]]
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[[Category: Gabrielsen M]]
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[[Category: Hunter, W N]]
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[[Category: Hunter WN]]
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[[Category: Bifunctional]]
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[[Category: Bifunctional enzyme]]
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[[Category: Biosynthetic pathway]]
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[[Category: Isoprenoid]]
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[[Category: Nonmevalonate]]
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[[Category: Transferase]]
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Current revision

Structure of the Bifunctional IspDF from Campylobacter jejuni

PDB ID 1w55

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