This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wb0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:26, 13 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
==specificity and affinity of natural product cyclopentapeptide inhibitor Argifin against human chitinaes==
+
 
-
<StructureSection load='1wb0' size='340' side='right' caption='[[1wb0]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
+
==specificity and affinity of natural product cyclopentapeptide inhibitor Argifin against human chitinase==
 +
<StructureSection load='1wb0' size='340' side='right'caption='[[1wb0]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1wb0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WB0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1wb0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WB0 FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=VR0:N~5~-[N-(METHYLCARBAMOYL)CARBAMIMIDOYL]-L-ORNITHINE'>VR0</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VR0:N~5~-[N-(METHYLCARBAMOYL)CARBAMIMIDOYL]-L-ORNITHINE'>VR0</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1guv|1guv]], [[1hki|1hki]], [[1hkj|1hkj]], [[1hkk|1hkk]], [[1hkm|1hkm]], [[1lg1|1lg1]], [[1lg2|1lg2]], [[1lq0|1lq0]], [[1waw|1waw]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wb0 OCA], [https://pdbe.org/1wb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wb0 ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wb0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wb0 RCSB], [http://www.ebi.ac.uk/pdbsum/1wb0 PDBsum]</span></td></tr>
+
== Function ==
-
<table>
+
[https://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wb0_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wb0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wb0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 27: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 1wb0" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Chitinase|Chitinase]]
+
*[[Chitinase 3D structures|Chitinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Chitinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Aalten, D M.F Van.]]
+
[[Category: Large Structures]]
-
[[Category: Adams, D J.]]
+
[[Category: Synthetic construct]]
-
[[Category: Aerts, J M.F G.]]
+
[[Category: Adams DJ]]
-
[[Category: Boot, R G.]]
+
[[Category: Aerts JMFG]]
-
[[Category: Hodkinson, M.]]
+
[[Category: Boot RG]]
-
[[Category: Houston, D R.]]
+
[[Category: Hodkinson M]]
-
[[Category: Omura, S.]]
+
[[Category: Houston DR]]
-
[[Category: Rao, F V.]]
+
[[Category: Omura S]]
-
[[Category: Shiomi, K.]]
+
[[Category: Rao FV]]
-
[[Category: Carbohydrate metabolism]]
+
[[Category: Shiomi K]]
-
[[Category: Chitin degradation]]
+
[[Category: Van Aalten DMF]]
-
[[Category: Chitin-binding]]
+
-
[[Category: Chitinase inhibitor]]
+
-
[[Category: Cyclopentapeptide inhibitor]]
+
-
[[Category: Glycosidase]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+

Current revision

specificity and affinity of natural product cyclopentapeptide inhibitor Argifin against human chitinase

PDB ID 1wb0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wb0"
Personal tools