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1wcq

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<StructureSection load='1wcq' size='340' side='right'caption='[[1wcq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1wcq' size='340' side='right'caption='[[1wcq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wcq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micromonospora_viridifaciens"_routien "micromonospora viridifaciens" routien]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wcq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_viridifaciens Micromonospora viridifaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eur|1eur]], [[1eus|1eus]], [[1eut|1eut]], [[1euu|1euu]], [[1w8n|1w8n]], [[1w8o|1w8o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcq OCA], [https://pdbe.org/1wcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wcq RCSB], [https://www.ebi.ac.uk/pdbsum/1wcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wcq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcq OCA], [http://pdbe.org/1wcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wcq RCSB], [http://www.ebi.ac.uk/pdbsum/1wcq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wcq ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NANH_MICVI NANH_MICVI]] To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors.
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[https://www.uniprot.org/uniprot/NANH_MICVI NANH_MICVI] To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Sialidase|Sialidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micromonospora viridifaciens routien]]
 
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[[Category: Exo-alpha-sialidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bennet, A J]]
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[[Category: Micromonospora viridifaciens]]
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[[Category: Newstead, S]]
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[[Category: Bennet AJ]]
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[[Category: Taylor, G]]
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[[Category: Newstead S]]
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[[Category: Watson, J N]]
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[[Category: Taylor G]]
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[[Category: Glycosidase]]
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[[Category: Watson JN]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase neuraminidase]]
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[[Category: Micromonospora viridifacien]]
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[[Category: Sialidase]]
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Current revision

Mutagenesis of the Nucleophilic Tyrosine in a Bacterial Sialidase to Phenylalanine.

PDB ID 1wcq

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