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2bm2

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==HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE==
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<StructureSection load='2bm2' size='340' side='right' caption='[[2bm2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==human beta-II tryptase in complex with 4-(3-Aminomethyl-phenyl)- piperidin-1-yl-(5-phenethyl- pyridin-3-yl)-methanone==
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<StructureSection load='2bm2' size='340' side='right'caption='[[2bm2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bm2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BM2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BM2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PM2:1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE'>PM2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a0l|1a0l]], [[1aao|1aao]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PM2:1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE'>PM2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm2 OCA], [https://pdbe.org/2bm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bm2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bm2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm2 OCA], [http://pdbe.org/2bm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bm2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bm2 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
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[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/2bm2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/2bm2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Tryptase]]
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[[Category: Large Structures]]
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[[Category: Aldous, S]]
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[[Category: Aldous S]]
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[[Category: Astles, P]]
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[[Category: Astles P]]
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[[Category: Cairns, J]]
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[[Category: Cairns J]]
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[[Category: Czekaj, M]]
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[[Category: Czekaj M]]
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[[Category: Davidson, J]]
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[[Category: Davidson J]]
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[[Category: Dupuy, A]]
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[[Category: Dupuy A]]
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[[Category: Eastwood, P]]
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[[Category: Eastwood P]]
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[[Category: Engers, D]]
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[[Category: Engers D]]
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[[Category: Fenton, G]]
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[[Category: Fenton G]]
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[[Category: Gardyan, M]]
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[[Category: Gardyan M]]
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[[Category: Giardino, O]]
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[[Category: Giardino O]]
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[[Category: Guilloteau, J P]]
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[[Category: Guilloteau J-P]]
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[[Category: Harrison, T]]
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[[Category: Harrison T]]
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[[Category: Houille, O]]
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[[Category: Houille O]]
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[[Category: Kwong, J]]
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[[Category: Kwong J]]
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[[Category: Levell, J]]
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[[Category: Levell J]]
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[[Category: Liang, G]]
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[[Category: Liang G]]
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[[Category: Lim, H K]]
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[[Category: Lim H-K]]
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[[Category: Luo, Y]]
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[[Category: Luo Y]]
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[[Category: Maignan, S]]
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[[Category: Maignan S]]
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[[Category: Mathew, R]]
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[[Category: Mathew R]]
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[[Category: Mccarthy, C]]
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[[Category: Mccarthy C]]
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[[Category: Merriman, G]]
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[[Category: Merriman G]]
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[[Category: Morley, A]]
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[[Category: Morley A]]
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[[Category: Pauls, H]]
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[[Category: Pauls H]]
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[[Category: Pribish, J]]
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[[Category: Pribish J]]
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[[Category: Rebello, S]]
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[[Category: Rebello S]]
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[[Category: Romano, J]]
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[[Category: Romano J]]
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[[Category: Shen, L]]
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[[Category: Shen L]]
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[[Category: Sides, K]]
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[[Category: Sides K]]
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[[Category: Smith, K]]
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[[Category: Smith K]]
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[[Category: Tsay, J]]
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[[Category: Tsay J]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Watson, S]]
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[[Category: Watson S]]
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[[Category: Whiteley, B]]
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[[Category: Whiteley B]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Serine protease]]
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[[Category: Serine protease inhibitor]]
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Current revision

human beta-II tryptase in complex with 4-(3-Aminomethyl-phenyl)- piperidin-1-yl-(5-phenethyl- pyridin-3-yl)-methanone

PDB ID 2bm2

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